- Eagan, J. W.
- Eagle, White
- Earhart, Amelia – American aviator
- Eastwood, Clint – American movie actor & director
- Eban, Abba – Israeli (S. African-born) diplomat & politician
- Eberhardt, Isabelle
- Ebers, Georg
- Ecclesiastes
- Ecclesiasticus
- Eckhart, Meister
- Eco, Umberto – Italian novelist & semiotician
- Eddington, Sir Arthur – English astronomer
- Edgeworth, Maria
- Edison, Thomas A. – American inventor
- Edwards, Bob
- Edwards, Tryon
- Ehrlich, Gretel
- Eibeschutz, Jonathan
- Einstein, Albert – American (German-born) physicist
- Eisenhower, Dwight D. – 34th president of US 1953-1961
- Eldridge, Paul
- Electra, Carmen – American actress
- Eliot, Charles W. – American educator
- Eliot, George – English novelist
- Eliot, T. S. – British (US-born) critic, dramatist & poet
- Ellington, Duke – American jazz bandleader, musician, & songwriter
- Elliot, Thomas
- Elliott, Hugh – Author of the Standing Room Only Weblog
- Ellis, Albert
- Ellis, Alice Thomas
- Ellis, Havelock – English sexual psychologist
| - Ellison, Harlan – American science fiction author & screenwriter
- Elmer-DeWitt, Philip
- Emerson, Ralph Waldo – American essayist & poet
- Emmons, Nathaniel
- Engels, Friedrich – German socialist & economist
- Englebreit, Mary
- Ennius
- Eno, Brian
- Ephron, Nora
- Epicharmus
- Epictetus – Roman (Greek-born) slave & Stoic philosopher
- Epicurus – Greek philosopher
- Erasmus, Desiderius – Dutch author, philosopher, & scholar
- Erdrich, Louise
- Erhard, Ludwig – German economist & politician
- Erskine, John – American author & educator
- Ertz, Susan
- Esar, Evan – American Humorist
- Eschenbach, Marie Ebner von
- Escher, M. C. – Dutch artist
- Estienne, Henri – French bookseller & printer
- Euripides – Greek tragic dramatist
- Evans, Greg
- Evans, Marian
- Evans, Noela
- Evenius
- Everage, Dame Edna – Australian Comedian (character of Barry Humphries)
- Everett, Edward – American clergyman, educator, orator, & politician
- Evert, Chris – American tennis player
- Ewing, Sam
- Ezra, Moses Ibn
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